Netter's Anatomy Practice Test 2026 - Free Anatomy Practice Questions and Study Guide

In skeletal muscle, the structure that wraps around a bundle of muscle fibers is the perimysium. This connective tissue sheath binds individual fibers into fascicles and carries the larger blood vessels and nerves that supply those fibers. It sits between the inner layer that surrounds each muscle fiber, the endomysium, and the outer layer that encloses the whole muscle, the epimysium. The sarcolemma is the plasma membrane of a single muscle fiber, not a wrap around a fascicle. So the perimysium is the correct covering for a fascicle, organizing multiple fibers and providing a conduit for the vessels and nerves that nourish them.